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However, alcohol also inhibits hepatic gluconeogenesisthe liver's production of glucosewhich can lead to delayed hypoglycemia, particularly several hours after drinking or when alcohol is consumed without adequate food intake

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Nonetheless, due to biological and physiological differences between a small animal model and humans, such as a thinner cartilage, possible spontaneous healing of defects, biomechanics, and physical loading in small animals, thus, an additional chondral defect repair study using minipigs should be conducted to confirm these effects