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In contrast, as mentioned above in a follow-up nested casecontrol study from the Nurses Health Study, it was reported that a combination of a polymorphism in the MnSOD gene together with the Leu/Leu genotype in the GPx-1 gene, confers a significant increased risk of breast cancer (80)

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Subsequently, the released ferrous/iron ions will react with excess hydrogen peroxide in the cell to produce a Fenton-like reaction generating hydroxyl free radicals (OH), and induce ferroptosis of tumor cells [205]

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