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It is difficult to design a vaccine that can induce both strong antibody and T-cell responses, but it is likely that a coordinated effort employing both arms of the adaptive immune response will be most effective

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It would be interesting to see if a longer time interval between vaccinations than the 3 weeks employed in this study changes the magnitude and type of immune response generated, as it does when reboosting with Ad/MVA encoding HCV antigens [150]