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Trimethylamine-N-oxide promotes vascular calcification through activation of NLRP3 (Nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and NF-B (Nuclear factor B) signals
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Non-equivalent or non-existing residues were identified near the N- and C-terminal regions
The two are structurally unrelated and act through different biological pathways, which is the main reason researchers became interested in studying them in combination
