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Maar et al

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Declining energy production, impaired DNA repair, oxidative stress, and chronic low-grade inflammation contribute to: Dull tone Reduced elasticity Textural changes Slower healing Increased sensitivity Accelerated visible aging NAD+ (nicotinamide adenine dinucleotide) is essential for cellular metabolism and repair

Patients in a depressive bipolar state exhibit a lower neuroprotective ratio (KYNA/3-HK), which strongly correlates with elevated IFN- levels [231]

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