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This epigenetic mechanism is consistent with the broader Khavinson framework for bioregulator peptides, which proposes that short peptide sequences (27 amino acids) can penetrate nuclear membranes and interact directly with DNA or chromatin-associated proteins to modulate tissue-specific gene expression

In particular, studies have examined its relationship with nitric oxide pathways and endothelial cell regulation

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Copper blocks V-ATPase activity and SNARE complex formation to inhibit yeast vacuole fusion