Dosage Amount Weeks 12: Inject 10 units (.25mg) Weeks 34: Inject 15 units (.50mg) Weeks 56: Inject 20 units (.75mg) Do not exceed 100 units (2.5mg) per injection Dosage Schedule Inject 1x/week, same night each week Recommended to inject at bedtime Notes Subcutaneous stomach injections If side effects occur, pause or maintain dose Increase dose slowly to avoid GI discomfort Refrigerate at all times Weekly dose may be split if needed CONVERSION KEY 10 units = 0.25mg 20 units = 0.50mg 30 units = 0.75mg 40 units = 1.00mg 50 units = 1.25mg 60 units = 1.50mg 70 units = 1.75mg 80 units = 2.00mg Semaglutide is a GLP-1 receptor agonist originally developed for type 2 diabetes but now widely used for effective and sustained fat loss
Timing: Some users find that timing injections relative to meals or taking them at specific times of day affects their symptom experience
3 By targeting the hypothalamus, Wegovy reduces hunger by promoting the feeling of fullness, leading to better control over food intake
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Some of this is likely attributable to the novelty of the triple mechanism, the higher efficacy driving more pronounced initial adaptation symptoms, and the fact that Phase 2 trial participants had less access to community experience about managing the adjustment period