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From genotype to phenotype: buffering mechanisms and the storage of genetic information

(8) These stimulants increase the release of norepinephrine a neurotransmitter that triggers a fight-or-flight response in your body

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These macrophages then release MMPs and ROS in large quantities, leading to the degradation of the ECM and the development of chronic inflammation (50)

While preclinical studies demonstrate that antioxidants (e.g., vitamin E, N-acetylcysteine, polyphenols) mitigate OS and improve vascular function in HTN/DM (Kaye et al., 2025)