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These interindividual differences highlight the need for incorporating objective measures of vagal function, such as baroreflex sensitivity or heart rate variability, into early-phase clinical trials

While this single case cannot establish a pattern, it raises questions about whether compounded formulations might carry different risk profiles due to variations in purity, concentration, or additional ingredients

A compounded version can cost significantly less than the brand name

Lawrenson JG, Hull CC, Downie LE

Power calculations suggest that previous studies would have had limited power to detect an effect size similar to that identified in our study (Supplementary Table 23), and also differed in terms of drug type, disease cohort and analytical choices