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While moderate coffee intake may have some positive effects, excessive caffeine can have the opposite impact

Human bone marrow mesenchymal stem cell injection in subchondral lesions of knee osteoarthritis: a prospective randomized study versus contralateral arthroplasty at a mean fifteen year follow-up

Abnormal tumor blood vessels form a barrier that limits the uniform distribution and effective delivery of anticancer drugs, making it difficult for drugs to fully penetrate the entire tumor tissue (Druzhkova et al., 2022

[DOI] [PubMed] [Google Scholar] 57.Corradi M

When the drug cannot reach sufficient intracellular concentrations, the cells may survive through intrinsic drug resistance mechanisms and gradually evolve into drug-resistant tumors