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The published human data is limited to topical skin applications and cosmetic endpoints

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When serum ferritin levels elevated, it causes exacerbated inflammatory conditions and induces oxidative damage and ferroptosis, along with the decrease in GSH levels (which functions as an oxidative stress regulator), creating a series of reactions that resulted in multiple organ failure, pulmonary injury, and reduced lung capacity in the study Group A

Lancet 397(10278):971984 Shi I, Khan SS, Yeh RW, Ho JE, Dahabreh IJ, Kazi DS (2025) Semaglutide Eligibility Across All Current Indications for US Adults