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doi:10.1016/j.neubiorev.2025.106159

Disruption of this axis (e.g., gut dysbiosis reducing SCFA production) is closely associated with MDD, as shown by reduced SCFA levels and altered microbiota composition (e.g., decreased Bifidobacterium ) in depressed patients (23, 24)

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When used locally with chemotherapeutic medications like oxaliplatin for breast cancer treatment, puerarin improved chemotherapy sensitivity, suppressed oxaliplatin-induced EMT, and inhibited the CAXII enzyme, which prevented type III drug resistance and breast cancer metastasis (139)