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Science 325 , 473477 (2009)

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Volcano plots comparing the TB001-treated group with the vehicle-treated group showed 494 up-regulated transcripts and 955 down-regulated transcripts ( Figure 4C )

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Moreover, valine pyrrolidide was also shown to increase the concentration of intact GIP, to prolong the half-life of GIP from 3 to 8 min and to potentiate the insulinotropic effect of GIP, resulting in enhanced glucose disappearance and a reduction in the glucose excursion after an intravenous glucose in anesthetized pigs (39)