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35 Thus, the clinical relevance of the results from the PIVENS study is limited

Institutional animal care and use committee statement: Male Albino Wistar, body weight 200 g, 12 weeks old, randomly assigned, used in all of the experiments, 6 rats/group/interval, approved by local Ethic Committee

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Various metabolites of MDMA including potentially toxic quinone and thioester compounds may directly or indirectly interfere with the mitochondrial electron transport system, leading to increased leakage of ROS from the mitochondria