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That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine

Patients should seek immediate medical attention for and discontinue semaglutide if they experience: Severe, persistent abdominal pain (possible pancreatitis) Signs of thyroid tumors (neck mass, difficulty swallowing, persistent hoarseness) Symptoms of gallbladder disease (right upper quadrant pain, especially after meals) Severe hypoglycemia (when combined with insulin or sulfonylureas) Signs of kidney problems (decreased urination, swelling, fatigue) Suicidal thoughts or behaviors (particularly with Wegovy) Vision changes (especially in patients with diabetes and pre-existing retinopathy) Regular follow-up with healthcare providers is essential to monitor treatment response, adjust dosing, manage side effects, and assess cardiovascular risk factors including blood pressure, glucose control, and lipid profiles

Brand-name Zepbound runs about $1,060 per month

Contact your healthcare provider if you experience: Severe abdominal pain or distention : May indicate bowel obstruction or other serious conditions

His experience demonstrates his belief in the programs effectiveness and enhances his commitment to helping patients achieve similar results