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Recently, a propensity score-matched study performed in a large cohort (9604) in Northern Sardinia, where the population prevalence of G6PD deficiency is the highest in the Mediterranean area, showed a link between G6PD deficiency and the risk of cardiovascular disease (CVD) [4]

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16 Moreover, more than 50% of subjects attending these clinics, representative of all diabetes subjects in Italy, would not be included in any of these trials