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In severe cases, it might trigger follicular hyperkeratosis, where keratin blocks hair follicles and potentially causes hair loss

When 1500 mg metformin or placebo was given with a mixed liquid meal in participants with well-controlled type 2 diabetes (mean HbA 1c 48 mmol/mol [6.5%]), the overall postprandial GLP-1 response was greater with metformin than placebo, but this increase was evident approximately 2 h after the meal [14]

doi:10.1186/1471-2407-9-56 65