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Aerobic training 3-5 times per week: Helps clear intramuscular lipid burden (DAGs) and improves hepatic control

Collectively, these findings suggest that GLP-1RA may ameliorate lipotoxicity through the PPAR/UCP2 axis, with UCP2 primarily modulating mitochondrial function through coordinated regulation of mtDNA content, MMP, and ADP/ATP ratio