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2 University of Liverpool, Institute of Systems, Molecular and Integrative Biology, Liverpool, UK The Journal of Headache and Pain 2026 , 27(S1): P128 Objective Transient receptor potential melastatin 3 (TRPM3) is a cation channel that contributes to activating trigeminal nerve fibres in neuropathic pain, While activation of trigeminal ganglion is essential for triggering light aversion behavior in mice