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Researchers pivoted to more selective compounds: afamelanotide for tanning indications and PT-141 for sexual function

UMN culture is an important tool to investigate UMN responses to treatment in vitro UCHL-eGFP is a reporter mouse line for corticospinal motor neurons (CSMN, a.k.a the UMNs in mice), in which CSMN express eGFP, and CSMN identity of eGFP+ neurons in the layer 5 of the motor cortex is confirmed by retrograde labeling, molecular marker expression and electrophysiological properties 31

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Aug 1990;52(2):383-390