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Cannot increase to a higher dose Sometimes, people do not feel as much appetite reduction with semaglutide because they are not able to increase to a higher dose, or they may not tolerate higher doses due to side effects like nausea or stomach upset, says Karalis, RD

Stunkard AJ, Messick S

The online health and wellness company is prepping to expand its digital weight loss program to Canada by selling a generic version of semaglutide, the ingredient in Novo Nordisk's branded blockbusters Ozempic and Wegovy

After 40 weeks, tirzepatide significantly outperformed placebo in both glycemic control and weight loss