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The FDA has also sent warning letters to multiple telehealth companies regarding compounded GLP-1 sales and marketing practices

The New York Times .

Retatrutide is an investigational amino acid peptide studied as atriple hormone receptor agonist, simultaneously targeting the GLP-1, GIP, and glucagon receptors to evaluate comprehensive metabolic effects in research

Given the wide use of these drugs, these adverse events, although rare, must be considered by patients who are contemplating using the drugs for weight loss because the risk-benefit calculus for this group might differ from that of those who use them for diabetes

In the TRIUMPH-4 Phase 3 trial disclosed by Lilly in March last year, the share of participants experiencing nausea over 68 weeks of treatment was 38.1% in the 9mg group and 43.2% in the 12mg group