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PMCID: PMC3180229.
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The main reason: the lack of randomized controlled clinical trials in humans
Caffeine is a methylxanthine that, in addition to increasing lipolytic effects on adipose cells, also suppresses the accumulation of intracellular lipid in adipocytes, inhibits insulin-stimulated glucose uptake and suppresses the differentiation of adipocytes derived from stem cells [25]
Antigen-presenting cells have the capability to mistakenly present their antigens to T cells, a process that triggers T cell-mediated autoimmune reactions and directly contributes to the development of RA (12, 13)
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