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176 The 2020 KDOQI guidelines recommend that adults with stage 35 CKD limit dietary phosphorus intake to maintain normal blood phosphate levels (2.54.5 mg/dL)

This analysis produced a list of 77 protein candidates, which were then clustered into gene ontology biological processes by DAVID Bioinformatics Database v6.8 (73) for further analysis

Also, according to the Center of Disease Control (CDC), approximately 40% of the adults living in the US have obesity (BMI 30 kg/m 2 ) and 9.4% have severe obesity (BMI 40 kg/m 2 )

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As such, the 2R-WGD event likely resulted in subfunctionalization and not in neofunctionalization