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[5] These are substantial effects for a naturally occurring tripeptide at physiological concentrations

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Interestingly, with progressive increase in IOP, autophagy is initially activated in the dendrites of RGCs and protects cells, but its subsequent activation in the cytoplasm disrupts homeostasis and induces cell death 21,22,70,71,72

doi: 10.1038/s41574-019-0176-8 9 MaCAvenellABollandMHudsonJStewartFRobertsonCet al