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Detailed evidence is provided by the study of Zhu, that when neurexin-1 is transcriptionally repressed and activated in neurons in vitro, it is enriched around its promoter by synthesizing zinc-finger protein (ZFP) to histone methyltransferase (Ash1L) and histone marker H3K36me2, respectively, and that the transcriptional repression of neurexin-1 disappears when Ash1L is turned off [85]

No direct human trial has evaluated this combination

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Adenoid (mouse): A layer of neoplastic cells surrounds luminal structures