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Interestingly, the tesofensine-treated rats also had lower levels of dopamine receptors in certain brain regions compared to both the placebo-treated rats and the rats on a restricted diet

As the loss of POLRMT results in severe mitochondrial dysfunction in cardiac muscle 70 , a similar mitochondrial dysfunction should occur in beta-cells with the loss or dysfunction of POLRMT, resulting in insulin resistance and diabetes mellitus

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In PD, the link to adaptive immunity was solidified by the discovery that peripheral T cells from PD patients can recognize -synuclein peptides presented by human leukocyte antigen molecules