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Generally, there is a corresponding antioxidant system to equilibrate oxidation

Elevated levels of reactive oxygen species can activate pro-inflammatory signaling cascades and apoptotic pathways, which in turn exacerbate neuroinflammation, impair neurogenesis, and contribute to synaptic and structural changes implicated in depression (104)

Staron, G

In the cardiovascular system, atherosclerosis becomes apparent as the invisible killer. Atherosclerosis causes cerebral ischemia, or angina pectoris, with the development of atherosclerotic plaques