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First, optimal dosing in humans remains undefined, with current practice based primarily on extrapolation from animal studies and anecdotal clinical experience rather than formal dose-finding studies

7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype

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Seminars in reproductive medicine: 2021