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In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075, and 0.15 mg/kg twice weekly (0.3-, 2-, and 4-fold the MRHD) were administered from Gestation Day 16 to 140

FIGURE 5 3.7 Anti-menopausal symptoms Menopause is characterized by the perturbation of the hypothalamic-pituitary-gonadal axis, including decreased estrogen levels, dysregulation of neurotransmitter such as serotonin, dopamine, and norepinephrine and an increase in the levels of the catabolic enzyme, monoamine oxidase A (MAO-A)all of which have been implicated in depressive symptoms and vasomotor instability (Table 1, Row 23) (Figure 5B)

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