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However, they also release neurotrophic factors in support of neurons 62 and they contribute to neuroprotection against glutamate excitotoxicity 63 and oxidative stress 64,65

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To test the effect of Sp in paraquat-induced oxidative stress model, seven days old wild type flies, constitutively expressing mitochondrial (mt)-roGFP, were exposed to 10 mM paraquat for 24 h and then co-treated with 2.5 mM Sp for 24 h, prior to roGFP fluorescence estimation