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[26] History [edit] The safety and effectiveness of dulaglutide were evaluated in six clinical trials in which 3,342 subjects with type 2 diabetes received dulaglutide

Demographics and baseline characteristics were similar between active treatment groups, whereas the placebo group had a slightly greater baseline body weight, greater proportions of participants in higher BMI groups, and a greater proportion of participants with 5 or more comorbidities (Table 1)

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Of note, the adaptor protein IRS1 not only binds to IGF-IR, but also interacts with EGFR/ErbB3

Indar 2002