In senescence-accelerated murine models, TERT activation by Epithalon correlates with increased median and maximal lifespan, reduced incidence of cytogenetic anomalies in bone marrow metaphases, and improved resistance to oxidative and genotoxic stress 2,4
Furthermore, in a human study, rikkunshito treatment notably increased ghrelin and the ghrelin/desacyl-ghrelin ratio, whereas the levels of desacyl-ghrelin exhibited a declining pattern (133)
It is a progressive condition eventually leading to kidney failure requiring dialysis or kidney transplantation and is associated with premature death, mostly from heart disease
Reactive metabolites from lipid peroxidation disrupt essential cellular structures, initiating cell death and DAMP releasea process further amplified by antioxidant depletion and exemplified in SLE, where neutrophils undergo ferroptosis and NETosis, activating TLR-dependent ROS generation that propagates inflammatory tissue injury (76, 87, 113115)
They theorized that this increased energy was part of acetyl-L-carnitines therapeutic benefits