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During oxygenated or oxygen-deprived states, hypoxia-inducible factor 1 (HIF-1) promotes Th17 differentiation by directly transcriptionally activating RORt and facilitating the formation of a tertiary complex comprising RORt, p300, and HIF-1 at the IL-17 promoter region [41]
(December 2019)
The peptide's exceptional selectivity for senescent cells, combined with its well-characterized mechanism of FOXO4-p53 interaction disruption, provides researchers with powerful capabilities for investigating senescence biology that were previously impossible to study
Cardioprotection by exenatide: A novel mechanism via improving mitochondrial function involving the GLP-1 receptor/cAMP/PKA pathway
Chinen, Lori
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