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Although L-tyrosine is a non-essential amino acid that can be synthesized endogenously from phenylalanine via the enzyme phenylalanine hydroxylase, its synthesis may become insufficient under conditions of physiological stress, rapid growth, or limited phenylalanine availability [71]

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Interestingly, estrogen receptors ER and ER are located in the axons and synaptic terminals of pre-synaptic cells and also in the dendritic spines (structures crucial for synaptic transmission) of post-synaptic cells (McEwen and Milner, 2007), indicating a role in local regulation of synapsis instead of exerting an effect at nuclear transcription (Zarate et al., 2017)

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