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The mechanisms underlying these effects include modulation of the skin immune response by suppressing the production of inflammatory cytokines, such as interleukin (IL)-1 and tumor necrosis factor-alpha (TNF), and increasing the production of anti-inflammatory cytokines, such as IL-4 and IL-10, therefore promoting a favorable environment for tissue healing and reducing inflammation (Routley and Ashcroft, 2009

The data showed dose-response relationships for both the benefits and the side effects (i.e., the higher the dose, the higher the efficacy and the greater the rate of bothersome side effects)

doi: 10.31887/DCNS.2009.11.2/cqiu 114 PlassmanBLLangaKMFisherGGHeeringaSGWeirDROfstedalMBet al