glp-1 birth defects TLDR on receptor agonists (ozempic, wegovy, monjauro, zepbound etc etc) animal studies suggest a possible association with defects, low fetal weight, and miscarriage but human data (which GLP-1-Mediated Pregnancy and Neonatal Complications

Figure 2 2.2.2.2 BL regulates adaptive immunity in PD Postmortem analyses of PD patients and animal models consistently reveal significant blood-brain barrier disruption, accompanied by enhanced peripheral immune cell migration and prominent T cell infiltration (predominantly CD3 + , CD4 + , and CD8 + subsets) within the substantia nigra (Tansey et al., 2022

The modern hallmarks-of-aging framework makes this clear

These beneficial effects were stronger for longer durations (12 weeks) and higher doses (2 grams) of supplementation and in participants with obesity, diabetes, or elevated levels of fasting blood glucose (100 mg/dL) at baseline

doi: 10.1126/science.280.5370.1763