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However, in contrast, a 2020 analysis that looked at berberine studies found essentially no significant weight loss effect at all (just 0.25 pounds on averageabout the weight of a small apple)

Oxidative stress associated DNA damage in testis of mice: induction of abnormal sperms and effects on fertility

10.1007/s00726-020-02823-6 36 YanR.ZhangP.ShenS.ZengY.WangT.ChenZ.et al (2024)

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It works by mimicking natural hormones to enhance insulin secretion and regulate appetite