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NSAIDs Example: Ibuprofen, Aleve Increase risk of GI bleeding or irritation, especially if nausea is already present on a GLP-1 Use only as needed and avoid on an empty stomach

97 Borbjerg, M

Starting at 1mg triggers MC4R-mediated nausea and flushing in 5070% of nave users

6 These are precisely the domains in which retatrutide has shown activity in non-PCOS populations, which is what makes the extrapolation tempting and what makes rigorous, PCOS-specific testing so necessary before any claim of benefit is made