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Preclinical models consistently showed accelerated wound closure, enhanced angiogenesis, and improved collagen organization compared with non-responsive scaffolds

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Furthermore, SGLT-2i have been linked to elevated SCFA levels in the colon, specifically butyrate and acetate, which are known to affect insulin sensitivity, glucose homeostasis, and appetite control and protect from kidney and cardiovascular disease [14, 35]

Proper dose escalation is crucial to maximizing benefits while minimizing side effects

Glutathione system activator Other than providing raw materials for the GSH system, another antioxidant strategy that activates the glutathione system is often achieved through medicinal therapy