In humans, GLP-1As have already been related to an increase in neoplasms development, such as pancreatic adenocarcinoma and thyroid C-cell tumor, but recent meta-analyses of randomized controlled trials failed to show any significant increase in cancer risk (Cao, Yang & Zhou, 2019
In terms of safety, sermorelins effects are considered more physiologic
If confirmed, treatment with semaglutide should not be restarted Gallbladder problems : Rapid weight loss can increase the risk of gallstones, which may cause right upper abdominal pain, fever, or yellowing of the skin/eyes (jaundice) Diabetic retinopathy complications : Patients with existing eye disease should be monitored closely, especially during periods of rapid improvement in blood glucose control [22] [23] Acute kidney injury : Usually associated with severe dehydration from gastrointestinal side effects Allergic reactions, though rare, can occur and may present as rash, itching, or difficulty breathing
The best choice depends on your individual health profile, weight loss goals, and medical history
Patients should also report skin symptoms if they are accompanied by systemic signs such as fever, malaise, joint pain, or other concerning symptoms that might suggest a more serious adverse reaction
