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Compared with unexposed pregnancies, the GLP-1 RA-exposed group had a higher risk for excess gestational weight gain (risk ratio, 1.32), greater mean birth weight percentile (58.4 versus 54.8 percent), and a higher risk for preterm delivery, gestational diabetes, and hypertensive disorders of pregnancy (risk ratios, 1.34, 1.30, and 1.29, respectively)

Its also a substrate for SIRT1, a family of enzymes involved in DNA repair, DNA silencing and metabolic regulation

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Risk Stratification (CAD Probability) High-risk patients (diabetes, hypertension, smoking history) approved Intermediate risk conditional (documentation-dependent) Low-risk or screening use denied 4