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Because T is derived from rate constants and does not have a physiologic basis, it is influenced by the sensitivity of the analytical method and by many pharmacokinetic parameters, and it is a poor parameter alone to evaluate physiologic (e.g., age, sex) or pathologic (e.g., renal failure) changes that effect drug disposition

Tirzepatide may feel more potent for some patients, which can be helpful when appetite is a major barrier, but it can also mean a rougher adjustment period in certain cases

Using them without the guidance of a qualified medical team is risky and irresponsible