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Suppresses Glucagon Release: GLP-1 inhibits the secretion of glucagon from pancreatic alpha cells
The key rule is maintaining minimum spacing between doses: Semaglutide: minimum 48 hours (2 days) between doses when shifting injection day Tirzepatide: minimum 72 hours (3 days) between doses when shifting injection day Retatrutide: follow your research protocol spacing, typically weekly If you fly east (losing hours), your injection day arrives sooner than expected
For semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda), the Summaries of Product Characteristics confirm that the injection site does not significantly affect the pharmacokinetics of these medications
Also avoid rushing the device away from the skin because of discomfort