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Basic research supports this mechanism, demonstrating that fructose or HFD exposure induces mitochondrial structural abnormalities, mtDNA depletion, and ATP deficiency, ultimately impairing -oxidation and hepatocyte function

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Infections and acute illnesses , including viral gastroenteritis, food poisoning, or antibiotic-associated diarrhoea, may coincidentally occur when someone has recently started B12 supplementation

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