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The number of studied VPA metabolites is close to fifty [97], but their clinical role (Figure 3) in the expected therapeutic response to valproate has not yet been sufficiently studied for many of them

We followed PRISMA guidelines for systematic reviews to ensure transparency and completeness in our reporting [14]

To describe outcomes that are associated with cannabis use during adolescence To name the receptor in the human central nervous system that nicotine binds to To view or add a comment, sign in Understanding Opioid Drug Addiction: Why Brain Chemistry Makes Quitting Hard Key Takeaways Drug addiction, especially to opioids, changes the brains circuits for stress and reward in a significant manner

doi: 10.1001/jamainternmed.2019.4802

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