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Weeks 1 through 4: 0.25mg per week (1mg total used over 4 weeks) Weeks 5 through 8: 0.5mg per week (2mg total used over 4 weeks) Weeks 9 through 12: 1.0mg per week (4mg total used over 4 weeks) Weeks 13 through 16: 1.7mg per week (6.8mg total used over 4 weeks) Week 17 onward: 2.4mg per week (maintenance dose) During the first four weeks at 0.25mg weekly, you use only 1mg from your 10mg vial

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By activating GLP-1, GIP, and glucagon receptors simultaneously, retatrutide exerts powerful effects on gut motility that can cause diarrhoea, constipation, nausea, and abdominal discomfort

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doi: 10.1186/s12933-023-02096-9