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24 July 2023

Together with the absence of symptoms associated with IGF-1-mediated effects such as fluid retention, tissue edema, or impaired glucose tolerance, these results demonstrate that AOD-9604 does not activate the growth hormone/IGF-1 pathway and therefore functions through an entirely appetite-independent mechanism

"ACHIEVE-1 is the first of seven Phase III studies examining the safety and efficacy of orforglipron across people with diabetes and obesity

In highly oxygenated tissues (e.g., lungs), carbon-centered radicals can react with molecular oxygen to form peroxyl radicals (ROO-CAR-OO )

Short-term symptom relief replaces long-term remodeling