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This is in contrast to orforglipron, a recently [US-approved] oral GLP-1, whose active ingredient is a small molecule and shows comparable weight loss to oral Wegovy

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Biological and metabolic factors (largely theoretical for retatrutide): Hormonal profile: It is hypothesised that individuals with differing baseline levels of GLP-1, GIP, and glucagon may respond differently to receptor stimulation, but this has not been formally demonstrated for retatrutide and should be regarded as speculative