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The time to first occurrence of MACE with TRESIBA as compared to insulin glargine U-100 was non-inferior (HR: 0.91
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The effect is dose-dependent, with higher doses producing longer gastric transit times, and the article notes most people adapt within about two to four weeks as the gastrointestinal system acclimates
injections are used in pregnancy only when the potential benefit clearly outweighs any theoretical risk
doi: 10.1016/j.npep.2012.07.004
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